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2022 1

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ABC-F family proteins 1

Antibiotic resistance 1

Ribosome 1

SrpA 1

Streptococcus suis 1

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Characterization of a Novel Gene, srpA, Conferring Resistance to Streptogramin A, Pleuromutilins, and Lincosamides in Streptococcus suis Article

Chaoyang Zhang, Lu Liu, Peng Zhang, Jingpo Cui, Xiaoxia Qin, Lichao Ma, Kun Han, Zhanhui Wang, Shaolin Wang, Shuangyang Ding, Zhangqi Shen

Engineering 2022, Volume 9, Issue 2,   Pages 85-94 doi: 10.1016/j.eng.2020.12.015

Abstract: Numerous ribosome-targeting antibiotics, especially pleuromutilins, oxazolidinones, and streptograminsIn SrpA-ribosome docked compounds, the extended loop region of SrpA approaches the valnemulinbindingpocket in the ribosome peptidyl-transferase center and competes with bound valnemulin.Intracellular antibiotics accumulation indicated that SrpA does not act as an efflux pump, while a ribosomebinding assay supported the protective effects of SrpA on the ribosome by preventing antibiotic binding

Keywords： SrpA     Streptococcus suis     Antibiotic resistance     Ribosome     ABC-F family proteins    

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Characterization of a Novel Gene, srpA, Conferring Resistance to Streptogramin A, Pleuromutilins, and Lincosamides in Streptococcus suis

Chaoyang Zhang, Lu Liu, Peng Zhang, Jingpo Cui, Xiaoxia Qin, Lichao Ma, Kun Han, Zhanhui Wang, Shaolin Wang, Shuangyang Ding, Zhangqi Shen

Journal Article